CIHM 
Microfiche 
Series 
(Monographs) 


ICMH 

Collection  de 
microfiches 
(monographies) 


ranadliin  Institute  for  Historical  Microroproductions  /  instltut  canadien  de  microroproducbons  historiques 


I 


Technical  and  Bibliographic  Notes  /  Notes  techniques  et  bibliographiques 


The  Inc-ti'ute  has  attempted  to  obtain  the  best  original 
copy  available  for  filming.  Features  of  this  copy  which 
may  be  bibliographically  unique,  which  may  alter  any  of 
tno  images  in  the  reproduction,  or  which  may 
significantly  change  the  usual  method  of  filming  are 
checked  below. 


□    Coloured  covers  / 
Couverture  de  couleur 

I      I    Covers  damaged  / 


Couverture  endommagee 

Covdrs  restored  and/or  laminated  / 
Couverture  restauree  et/ou  pelliculee 


D 

Cover  title  missing  /  Le  titre  de  couverture  manque 
I I    Coloured  maps  /  Cartes  geographiques  en  couleur 

□    Coloured  ink  (i.e.  other  than  blue  or  black)  / 
Encre  de  couleur  (i.e.  autre  que  bleue  ou  noire) 

I       I    Coloured  plates  and/or  illustrations  / 


D 


Planches  et/ou  illustrations  en  couleur 

Bound  with  o'    jr  material  / 
Relie  avec  d'autres  documents 

Only  edition  available  / 
Seule  edition  disponible 

Tight  binding  may  causf?  shadows  or  distortion  along 
interior  margin  /  La  reliure  serree  peut  causer  de 
I'ombre  ou  de  la  distorsion  le  long  de  la  marge 
interieure. 

Blank  leaves  added  during  restorations  may  appear 
within  the  text.  Whenever  possible,  these  have  been 
omitted  from  filming  /  II  se  peut  que  certaines  pages 
blanches  ajoutees  lors  d'une  restauraticn 
apparaissent  dans  le  texte,  mais,  lorsque  cela  etait 
possible,  ces  pages  n'ont  pas  cle  filmees- 

Additionai  comments  / 
Commontaires  supplemcntaires; 


L'Institut  a  microfilme  le  meilleur  exemplaire  qu'il  lui  a 
ete  possible  de  se  procurer.  Les  details  de  cet  exem- 
plaire qui  sont  peut-etre  uniques  du  point  de  vue  bibli- 
ographique,  qui  peuvent  modifier  une  image  reproduite, 
ou  qui  peuvent  exiger  une  modification  dans  la  metho- 
de  normale  de  filmage  sont  indiques  ci-dessous. 

Coloured  pages  /  Pages  de  couleur 

Pages  damaged  /  Pages  endommagees 


Pages  restored  and/or  laminated  / 
Pages  re,staurees  et/ou  pelliculees 


□ 


j      I    Pages  discoloured,  stained  or  foxed  / 

n 


Pages  decolorees,  tachetees  ou  piquees 
Pages  detached  /  Pages  detachees 
Showthrough  /  Transparence 
I    n    Quality  of  print  vanes  / 


n 


Qualitc  negale  de  I'impression 

Includes  supplementary  material  / 
Comprend  du  materiel  supplemertaire 

Pages  wholly  or  partially  obscured  by  errata  slips, 
tissues,  etc.,  have  been  refilmed  to  ensure  the  best 
possible  image  /  Les  pages  totalement  ou 
partiellement  obscurcies  par  un  feuillet  d'errata.  une 
pelure,  etc.,  ont  ete  filmees  a  nouveau  de  fa^on  a 
obtenir  la  meilleure  image  possible. 

Opposing  pages  with  varying  colouration  or 
discolourations  are  filmed  twice  lo  ensure  the  best 
possible  image  /  Les  pages  s'opposant  ayant  Ces 
colorations  variables  ou  des  decolorations  sont 
filmees  deux  fois  afin  d'obtenir  la  meilleure  image 
possible. 


This  Item  is  (ilmed  at  the  reduction  ratio  checked  brinw  / 

Co  dncyrri^nt  95I  filmp  nii  t^ijir  tin  rpriijrtinn  inrjinup  ri.rio^^nijc 


10x 

14x 

18x 

22x 

26x 

30x 

1    1 

1    1 

1 

1   „ 

12x 


16x 


20x 


24x 


28x 


32x 


The  copy  filmed  here  has  been  reproduced  thanks 
to  the  generosity  of: 

J.J.    Talman  Regional    Collection, 
D.B.   Weldon  Library, 
University  of  Western  Ontario 

The  images  appearing  here  are  the  best  quality 
possible  considering  the  condition  and  legibility 
of  the  original  copy  and  in  keeping  with  the 
filming  contract  specifications. 


L'exemplaire  film^  fut  reproduii  grace  i  la 
g^n^rositd  de: 

J.J.    Talman  Regional    Collection, 
D.B.   Weldon  Library, 
University  of  Western  Ontario 

Les  images  suivantes  ont  6xi  reproduites  avec  le 
plus  grand  soin.  compte  tenu  de  la  condition  et 
de  la  nettetA  de  I'exempjaire  film^,  et  en 
conformit*  avec  les  conditions  du  contrat  de 
fiimage. 


Onginal  copies  in  printed  paper  covers  are  filmed 
beginning  with  the  front  cover  and  ending  on 
the  last  page  with  a  printed  or  illustrated  impres- 
sion, or  the  back  cover  when  appropriate.  All 
other  original  copies  are  filmed  beginning  on  the 
first  page  with  a  printed  or  illustrated  impres- 
sion, and  ending  on  the  last  page  with  a  printed 
or  illustrated  impression. 


Les  exemplaires  originaux  dont  la  couverture  en 
pepier  est  imprim*e  sont  filmAs  en  commencant 
par  le  premier  plat  et  en  terminant  soit  par  la 
derniAre  page  qui  comporte  une  empreinte 
d'impression  ou  d'illustration.  soit  par  le  second 
plat,  selon  le  cas.  Tous  les  autres  exemplaires 
originaux  sont  film^s  en  commenpant  par  la 
premiere  page  qui  comporte  une  empreinte 
d'impression  ou  d'illustration  et  en  terminant  par 
la  derniAre  page  qui  comporte  une  telle 
empreinte. 


The  last  recorded  frame  on  each  microfiche 
shall  contain  the  symbol  — h^  (meaning    "CON- 
TINUED"), or  the  symbol  V  (meaning  "END"). 
whichever  applies. 


Un  des  symboles  suivants  apparaitra  sur  la 
derniAre  image  de  cheque  microfiche,  selon  le 
cas:  le  symbole  -^»- signifie  "A  SUIVRE '.  le 
symbole  V  signifie  "FIN". 


•'vlaps,  plates,  charts,  etc..  may  be  filmed  at 
different  reduction  ratios.  Those  too  large  to  be 
entirely  included  in  one  exposure  are  filmed 
beginning  in  the  upper  left  hand  corner,  left  to 
right  and  top  to  bottom,  as  many  frames  as 
required.  The  following  diagrams  illustrate  the 
method: 


Les  cartes,  planches,  tableaux,  etc..  peuvent  etre 
filmis  i  des  taux  de  /Eduction  diff^rents. 
Lorsque  le  document  est  trop  grand  pour  etre 
reproduit  en  un  seul  cliche,  il  est  film^  d  partir 
de  Tangle  supArieur  gauche,  de  gauche  d  droite. 
et  de  haut  en  bas.  en  prenant  le  nombre 
d'images  nAcessaire.  Les  diagrammes  suivants 
illustrent  la  m^thode. 


1 

2 

3 

1 

2 

3 

4 

5 

6 

MICROCOPY    RESOLUTION    TEST    CHART 

ANSI  and  ISO  TEST  CHART  No    2 


1.0 


I.I 


^^    lllljM 

3  J 


I  2.2 

|36         '""  = 

!~    mil  2.0 

mil  1.8 


1.25 


1.4 


^     .^IPPLIED  INA^GE     Inc 


T4609        LS* 


Subcutaneous   Purgatives 

A   (linuai    Sruih'  on  Phcii<)ltctr:ic!!l'»rpluluikin 


i; '.  w  \  I  i;  I-;  r; 

l;  \  1  I  :  \iM|;i 


I  ■   ■       1 1-1/     ',1     (/..        Ici.  ,  ..ll.l       \l'lllllll 

'■I ■(   ■•   /;<;".  i'til.  I.ir.  lyi.  :^^:;^^ 


SL'BClTAXKol  >    I'(i;(,aT[\'ES 

A  .  i.iMcAr.  sTL-i)v  o.\  i'i!i:N()i.ri:Ti;Aciir.,.Ri'itTi[.u.[:ix  * 


,,""■';  "';;j"tnHln,t,un   „r  ,1,,.  l,v,HH|,.r,nu.   ,„.,,||,.   |,v 
^l.^.n,lu•\\,..|o|■Kdi^l.,r^h  in  ji,;i.  ,,,,,„.J'.,   , 
,.i-w,n,-  t,.,.,l,.,„.v  In  Tviv  „,o,v  an.l   ,noiv  on  t 

-;-'--'    tlH.i.Ha.luu  , In.  nH.iuKi  insures  n^uiio^: 


-Mc.li.in,.  >i;in,ls  11,  ncci  ,,r  ;i  sul,,  iitan 


■ate 

(■(Ills   pUro;ilti\7'. 


d. 


I  '-"  '  ^""1  >ur^...n  alike  hav.  m.-^ni.;,!  i, 
'  .  "it.N.  1  ].arn,ac(.l,.i:i>t.  and  ('-X|((.rinu.ntal'i;,erap..u 
n-t^  have  ivpcatodly  attempted  to  stn.plv  tin.  den  Ind 
<unnng  sn.-eessively  to  .lie  ^alines,  to  t  ,J  ve-'etable  nnr 
P.nve.  and  to  ,I,e  aikahdd.  Knt  still  the  S  E  ' 
'"'  ""  preparation  suggested  has  as  vet  tuHilled  tie 
'lUnienuN  mpurenients  demanded  nf  it  Such  a  ho.  • 
;.;-t  a,,  on  the  intestinal  tra.  t  and  on  the  int^.  n  I 
"'"•'  ""Iv  "itl.out  any  untoward  etlVo^  on  anv  other 
nrj^an  (,r  <yste,n,  n.u.t  act  with  eertaintv.  must  he  read- 
.  >  .oluh  e   preterahlv  ,n  water,  in  .(rder'that  the  a.nount 

-  UK  ol,em,eet..,lmavhe.mall.anditm.sthe,^^^^^ 
i.u  ant  loeallv.  As  a  rule  ii  sh,a,ld  pr.Khu-e  its  ..freef 
-.  Inn  a  .hort  tune.  al,ho„gl,  ,„  ,.,„!„.  ,„„ditio„s  ,; 
;"""n  delayed  ,n  onset  hut  j.rolono,.,!  in  e|,,,raeter  is 
lie  pi'elerred. 


■V  IS  to 


In  tin- 


ni-  e.mneetion  i  i>  ,n(ere>ting  to  r,vu.w  the  lii- 
•■';""i-"  dealing  wiih  the  suluutaneous  and  mtravenou. 
adnmnstration  ol  the  saline  purgativev  \uheii'  ,,,,ed 
'"  ''^■''  "'^  nilravenous  injections  of  sod  mm  sulphate 

ul   Ailantif  chy.  Jiiii,'.    1;hi:i.  ■'>■'<•  ■\<  Annu.il  husssiun,  Inla 

I    Zts.lic.  f.  lat.  Med.,  IS.-.:;,  ii.  ■■■..-, 


pi'iiilui,'  |iiiiuiil  i\  r  riTfi-i-.  I  laihlr  I'lfriiiii'il-  ip;iilc  a 
>iiiiihir  -  tali'innil  in  is'il  and  lli'adlaml-  in  ls'i'.». 
lliii\i,iiii  nrilhcr  nf  tln^  |a~t  wialrrs  uavi'  any  i'\|M'i'inirntal 
proiif  I'm-  lii>  (  iaini.  llnclilirini/  Wai:ncr.''  and  lfa\" 
(■■im  hidi'd.  alirr  a  (  on-idiiaMi'  anmnni  nl'  cNiiri-inirnia- 
iHin,  ilial  -iidinni  -nlpliatc  i  \ii1>  nn  |iiii'i.mI  i\  <■  ailinn  i  I' 
j:ivi'n  inl  I a\cni)ii-l \  ur  >iil»-iiianr(iii~l\ .  anil  tlii-  'la-  ln'cn 
till'  r(inrlii~iiin  nf  |  irait 'h  a  1 1  \  all  in\r~t  iijaiur-  ;n  llii- 
licld  uniil  till  apiii'ai'anc'  nl'  a  |ia[M'r  hy  .1.  I'>.  MacCal- 
Inni.'   wliirli  iicat'Ml  a  nr\\    iiiirrc-i  in  Ihi-  >iiliji(t. 

Marl  alliiiii  iiil  iiidi!(  I'll  M.!iiti()n>  n','  ihr  \aiiiiii.-  -alinr~ 
intii  ilii  \riii-  iir  iindrr  the  >kin  nf  i'aliliil>.  and  tlicn 
>liidi"d  the  inVcl  on  nio\riiiiait~  (d  tlii'  Miti-iini'-  ritlior 
hv  Ml)>cr\inL;'  llic  innvriiiriiN  <i{  iiiiislino  tiii'imuh  tliii 
iipt'niMl  al  dniiiinal  wall  nr  li\  nli-cr\aticiiis  niadi'  im  tlic-o 
animals  ■•nnlinid  in  ~c|iaiaic  iiK'taliiilisni  caucr-.  fl.'  cnn- 
cliidi'd  tliai  all  ilici-i'  .-all-  wliicli  ait  a-  iinr;:al  i\  >■-  wlicn 
iiit  nidiiccd  iiiiii  the  >li)iiiarh  111'  inli'>linc-  lia\r  the  >aiiu' 
acliiin  wIh'Ii  injritt'd  siiIk  iilanrdii-ly  nr  iiil  im\  I'limwlx . 
He  ai-n  -laird  lliat  l)iiriiini  ddjirid  )i(is-c>>i'.-  tlii-  |iiir^ii- 

\\\^^   jHiJlirrly    111   lllr   i;i-cali'-l    dfUMTC.    liut   all    nf   tile   iilluT 

saiiiK'-  |iu-M--s  it  111  a  li'--  dc'Lii'i'r.  tlial  llir  |nirL:aii\i> 
rlFnt  i-  [irndiiri'd  liy  I n> i't'a.-i'd  M'ciTiiiin  a^  well  a-  in- 
creased |ii'ri-tal>i-.  and  tliat  tlii'  niiriiative  ellVit  can  lie 
connterac-ted  ni'  aimlislied  hy  (aleiiini  elihn'id. 

Ami'  iii\e-t  iiiated  in  ilii'  >anie  llidd.  lint  enuld  iioL 
iililain  MacCallnnr-  re>iilis,  and  claimed  that  in  his  ex- 
|iiiinients  >(idiiini  citrate  used  intravcnoush  caused  ron- 
>ti|iatiiin.  while  ma;;ne<!!iiii  .-iil|iha(e  inhiliitcd  iiiie-linal 
mii\cmenls. 

liaiiii'iilf  re|iealid  Alai CalhimV  \Mirk  and  >talcil  thai 
-miiiini  citrate  nr  liai'iiim  chluiid  -iiliciitaneiin>l\  and 
-.iidiiim  -iilplialc  iiitra\eniinsly  act  a>  |inr::ali\es.  lint 
I  hat  it  I-  ca>ier  In  |iriidiiie  Ihiid  feces  li\  admiiii-teriiiL,' 
-ii'linm  >iil|ilialc  nr  -oiliiini  ciirale  liy  innn-ili. 

I'lckardt'"  ;;i\c-  an  excellent  review  (if  ihe  Wiirk  dune 
111  this  held  ll|i  to  l!ll'"i  and  ])resellts  also  the  le.-nlts  of 
his  own  exjieiimeiit-.  wliicli  eon(dnsi\('ly  prove  that  tiie 


;;.  Siib^-tancPS  Toxlquos  ol    .Miiliriiim  niinsos,    1857,  p.   85. 

:;  A.  liiiti  nf  MiMlliiiii'-.  isr,!i.  p.  t:,u 

1.  Aiili.   1',  pliv-^inl.   Ili'ilkiiiuii'.  ^s:,\.   \iii.  -JIT 

."..  Inaiiu.   I)i—  .   Iiiir|i;il.    l>-r,:i. 

I'l.  .Iiiiii'.    Aiiiil     anil    l'li\-iiil..   xvi.   ji;!. 

7  Am.  .Imir.   I'li.vsinl  ,  \.    lnl. 

"•  Ai)i.  Jiinr.   I'liysiiil  ,   wll.  l.'i. 

•I.  .I.jiu-.'ni'il.  <!ii'ip..  hi.   I'.il. 

Ill  liiiin.'    |ii--,   i;iis-.'ii.    IlKi.'i. 


3 


sjilinci  will  Jint  I'lirin-h  n-  thr  MiiiL:lit-l'iii-  -nlicutanf  ^l^ 
|)uri,''ativi'. 

.VltlinuLih  tlirsc  iii\  r>li;iat  iiui>  arc  nf  acadciiiic  and 
t^cii'iitiilr  interest.  tiie\  iiei|i  tn  liirou  some  liglit  on  tlie 
metlioil  (>(  aetidn  of  salines,  and.  although  intestinal 
peristalsis  is  iinduniUedly  ineieased  l)_v  some  at  lea>t  id 
tlie-(>  salts,  vet  the  increase  in  activitv  is  not  sntlicienlly 
markul  to  resnlt  in  jiuri^ation  nnl'.'ss  toxic  oi-  lethal 
d(i>c-  are  injected.  The  salines,  thei'efore,  are  df  no 
|iractiial  importaiici'  id  mcdicin;'  a-  ,-id)cntanr(in-  [inriia- 
tives 

Uarium  chlorid.  h<iu"e\cr.  will  pi-udii  i  |iuruatidn  ad- 
ministered either  ^nhc^taneull-l\•  cm  iin  i  i\t'nonsl\'.  a.iid 
it  is  l'rei|uently  u>ed  a-  such  hy  \eti'rinarians.  1  um. 
heiiiL"'  sutlicicnt  to  juira'e  a  horse  weiiihinu'  l.Odn  pimnds. 
Hut  hariuni  is  tiie  most  iioisuiions  of  the  alk'aline  eai'tli- 
and  it  atl'eet.s  many  oriians.  It  ac<'elerates  the  In  ii. 
enormously  raises  hl(Mid-pressure.  and  in  lai;ue  do.-c-. 
hesides  puriiing,  eaiise-  \ieniting  and  ximetimes  tonic 
and  clinmic  eonvulsion-.  'I'lie  widespread  nature  dl'  it- 
a(ti\ity  and  its  to\icit\'  jiicclude  its  general  aih:|)iidn  in 
tlil>  iield. 


\"i:i.i:t.\I!I.k  i'li!(;ati\i>  .\!)M1ni>tki;i;u  bnicr'TANKorsi.Y 

Similar  investigations  have  heeii  carried  on  with  the 
M'getahle  ]nirgati\-es.  aloes."  eoloeynth  and  catliartinic 
acid  having  been  tested,  lliller'-  regards  eolocynthin 
as  the  i:u).-t  suitable  fdi  this  purpose.  Xo  doulit  can 
e\i?t  as  to  their  ellicacy  when  so  used,  but  all  these 
bodies  are  strongly  irritant  ami  the  h)enl  reaction  at  the 
point  (if  injection  i>  fre([ucntl\-  extremely  severe.  'I'liev 
cannot  Ije  used  in  this  way  (\xce|it  mi  very  e\ct>|itidnal 
instances  where  the  indications  are  imperative,  and  then 
only  witii  ii  grave  po><ibilii\'  of  ploughing  occurring  at 
tlu^  ]ioint  of  injection. 

.\n  ollVirt  Vi'as  made  t(.  see  il  croton  oil  greatly  diluted 
could  be  used  ?ubcutaneousl\ .  'I'wo  drops  of  croton  oil 
were  added  to  5  c.( .  (d'  oli\('  oil  and  under  aseptic  pre- 
(autions  introduced  beiiealh  the  skin  of  a  dog.  On  the 
fiilldwing  day  a  ])ainful  ^welling  was  found  at  the  point 
(d'  injecti(jn.  This  increased  in  size,  became  very  tender, 
and  persisted  for  several  days.  Xo  evidence  of  an  action 
du  the  intestine  was  noted  until  the  fifth  day.  when  a 
large  amount  (100  gin.)  cd'  liuid  feces  was  passed.    The 

11.    lliins  Meyer:    .Vrch.  f.  cxpiT.   I'lUli  .  xxviii,   I HC. 
IJ.   Ztsdir.  f.   kiln.   .Me<l  .   iv,  4,sii, 


>|iHiU  ichiaiM.'il  -lilt   I'm-  ilii' hiv^Minl  lluii  icIiii'iiimI  to 

a    liul|||;l|   I  ii|l>i>trlli'y. 

.Vii  cxiicriiiH'iil  ui|li  la.-liir  nil  vidilt'il  n  \(t\'  >iiiiilai' 
n-iill.  A  (|(),'i  was  iiijriicd  w  itii  V'l  v.c  dl'  >1crilc  ca-tnr 
nil  on  Ucci'iiiliiT  \'i.  Nil  iMiruativc  cH'cit  \v,i~  nlitaiiu'il 
until  l>''C('inlicf  l.-^.  liiit  till.-  was  so  siiulit  in  dc^^fcr  tiiai 
It  was  ilunlitl'ni.  A  iafL:('  |iaiiil'iil  -wc'lliiiu  (iciiifi'c(l  at 
(lie  piiinl  III'  injection,  which  ))ci'sistc(l  iinlil  l>cccnilicr 
"'1.  it  is  -carccly  ])()>sililc  tliat  any  scrviccaMi  >iil)cii- 
laiiciin-  |iuiL!ati\c  will  he  nlitaiiicil  (nun  this  clas-  nf 
ill  llL:^. 

\co(  iii)i:i\ 

I'lic  wiiik'  ijiiiii'  with  apiiciidfin,  linwcvcf.  ha>  hccii 
iiiiifc  I'liiiti'iil.  'I'liis  is  an  alkaloid  cmTcspoiulinu  in 
ilci'ivatioii  til  a|iiiniiir|ihin  t>iiin  niofphiii,  ohtaiiicil  hy 
ilchyilratiiiL:'  ciiilciii.  It  wa-  lirst  cai'cl'iiliy  stiiilinl  hy 
(iiiiiiai'il.' '  lie  noted  that  it  jii'oilticcd  no  nausea  oi- 
vomitin^u',  anil  rnllowini:-  it-  ailininistfalion  he  oh-erveil 
the  iiiei'easeil  |ieii.-tal.-is  tlifoii^ih  ail  o|icii  alKlominal 
uall.  Miii'fcl"  UM'il  it  a-  an  e\|ieitoi'nnt  in  ISlll.  Toy'-'* 
as  a  M'ilati\c  in  maniacal  i  ases  in  IS!).").  ( 'onihenialc''"' 
iiUi'oiliurd  it  as  a  |uiri:ative  hy  mouth  in  l!)ini.  lie 
intef<sli'il  l{aviiirt  ami  ISartoii.''  who  in  the  -aine  \eai- 
ailniiiiistei'cil  it  suhcntaiieoiisU  in  :!  I  cases  ot'  constipa- 
tion with  \ei'y  ciicourauinii  results,  (iiraiiil.'"'  l!)():>. 
used  it  in  ■•>  cases  of  consti])atioii.  also  with  satisfaetorv 
results.  In  the  -ante  year  Ileiiize'"  tested  it  in  a  series 
of  :\o  eases  of  const ipat loll.  Tfe  l-ad  JT  ]ier  cent,  of 
-iicces-ful  cases  and  in  M!  ))er  cent,  it  utterly  failed, 
l-'i'oni  his  experience  lie  loiiciudes  that  ajiocodein  is  un- 
-atisfaetorv  in  that  it  i-  uncei-tain  in  action,  hut  admits 
that  it  work-  wvy  well  in  many  instances. 

The  dose  of  this  drill;  i-  small.  .0"2  ^mu.  of  the  IimIiti- 
liijorale  lieini:  usually  -uflicieiit.  while  .0.")  ;:iii.  i-  the 
maximal  dose,  ifost  of  the  writei's  claim  that  the  lir.-t 
ev.acuation  follows  .-hoitU  after  the  ailministrat ion  of 
the  injection,  freipieiilh  within  one  to  two  hours. 
Ilcinze.  liowcMM'.  -tale-  ijiat  the  aNcraire  lime  i-  from 
tell  to  t wehc  hours. 


i:i.  I.yiin  iiifil  .  IMi:;.  pii.  I'l   iiml  2S. 

1  4.  lirit     Mrd    .lour  .    IMil.   i,   i",. 

i."i.  SciiiMiiii'  iiii'ii..  is'.i.'i.  |i   :ut!. 

II)  Sriniiliii'  niril..   r.iiie.  p.  4-2. 

17.  I'.rhii  Tii.Hl.   ilii   iinrd.    lii'rcnihi'r.    lIMiJ. 

IS  I'Mr's.'  ill'   l.ynn.    r.iii:' 

111  r^v'iiiiii   Niiirni,  w.iiii^iiip-..   iim:;  I.  \.  :;;iT. 


'I'lic  iiliircti'in  ,  I  ,  111  •  M  ,in'  \Miilli\    i>f  (•(•ii~ji|(M-:i- 

tioii.  for  il  cfi'tinnlv  ilo,'~  •|,ii  iv|iiv-fn|  iln^  iilml  miIku- 
taiK'ous  |iMr,;iiiti\i'  us  uinliiicil  mIiovc.  Accord  ills':  t" 
hivHTi-'"  it  |o\vcr~  llic  !il(Mi(l  |irc>>iin".  dilates  tlic  art(  ri- 
n|, -.  iiiiivi-c-  |icri-tid-i-  i,\  it-  -cd:itivi'  acticui  nn  tlio 
inhil)it(iry  'iaiiuliii  of  ih,.  -\  mpatlict  ic  -\,~tcni.  inci-casis 
the  I'atc  (if  the  ill,  rt  heat,  ami  increases  ner\e  i-eth'.\e-. 
Its  actiiiii>  are  [mt  ihiiih  i-(r,i-  and  cnnipiex  fiinl  iimihe 
tui)  many  -vni|)tiini-.  rnl'nrtnnately.  althiuii.di  readilv 
Milulile  in  water,  it  i-  irritant,  locally.  nian\  of  tlie 
IMtienis  iiavinu-  c'un|i|aitieil  of  pain  ami  an  ahMc~s 
haviiii;-  I'olliiwcd  it-  ii>e  111  (iiie  rase.  It-  action  is  also 
short  in  duration.  c,,ii-t  ipat  ion  iisiiallv  rerni-nini;-  in  ;\ 
da\  or  two. 

XotwithsiandiiiL;'  the-e  drauhack-  a|i'.ci)ilein  i-.  Imw- 
i'\r\\  a  scr\ici'al)lc  hy|ioderiiiic  piiruali\c.  I'er-diial  e\- 
pei'ience  .lias  iieeii  limited  In  ardiiial  cxperinientatinn. 
On  (iiie  occasion  an  e\acnatioii  <>(  the  l)o\ve!<  t'olloued 
witliin  an  liour  of  the  in.jectioii  id"  0.0[  om.  ^nhi  ntane- 
onsl\-  in  a  do^.  In  other  in-taiices  nioveineiits  iKciirred 
within  ten  or  t\i-eive  hours,  hut  the  stool>  were  ui>[  ,-otl 
and  no  |iroiijn<>e(l  iutiijn  wa-  ohtained. 


i;si:i;iN 

Ksei'in  or  physosti^niin  ha-  al>o  ijceii  invesiioated. 
Dickerhoff-'  jiivt  siifrcjosted  its  use.  and  since  tlien  it 
has  lieeii  tried  cdinically  hv  many  investi^'ators.  vnn 
Xoorden.--  Packard.--  I'ankow.-*  Craiir.-^  .(ewott.-"  par- 
ticularly hy  surireons  and  obstetricians.  It  is  not  i:i\en 
solely  for  its  jnir-jative  etfcct  hut  most  freciuoiitTv  In 
pi'cveiit  or  overcome  intestinal  paresis  fnllowinp  surirical 
operations,  or  to  overcome  intestinal  atonv  followiiiL'' 
parturition,  or  to  e.'ipel  <:as  from  a  distended  intestine. 
Crai.i;-  has  nsed  it  extensively,  and  he  administers  it  ini- 
niediately  after  opening:  the  ahdomon  provided  iki  cdii- 
traindication  presents  itself.  He  claims  that  it  i-  of 
more  value  in  preventini:  or  wardintr  otT  threatened  in- 
testinal paresis  than  it  is  in  ( tiriiifr  this  condition  when 
once  estahlishcd.      He  a<lvises   lar^'i'  dosi^^.    1    ;!."■)   u-r.   n\' 


L'li.  .Iiim-.    rii.vslol..   xx\-,  ;i7. 

•-'1.  W.luisclii-.  f.  Thiorli.  ii.   Violiz  .  1SS:;.  xxwl.  .'lOO. 

--.  von   Noaidon  :     Ilcrl.   klin.   Wchnsdir..    IIKM.    p     l(i,-,7. 

i;.!.  riilladolpliia   Moi\.  .1mn\.  .Ma.v  IM.   limi'. 

J-t.  Z.'iitriilhl.   f.   <;.vn..   June.    ]li(M 

■J'l.  .\\u.   .Icjiu-.    Ohst..    A|ii-il,    irxM.      .\iii.    .Tniir.    f)l--t..    S.'iii.inli,.! 
19II-I.      .\,.tt    York   MimI.   Joiir..   I'to.".   Ixxxi,   .-,'.'T. 

:;i;.  I'.iridkl.vn   .Mcil,   .Icm-,    xlx.   -I'.V 


,,,„  ,^,,,,„,.  a,lininiMriv,l  .miM)  -iil,ruununu>h .  au.l  hv 
,,.,,,nN  Ibis  .w  r.M.ntK.l  I'nr  M.rr,.~~ful  .vMilt-.  aun  - 
utiiv  I'ankow-.  lack  nf   ivmiIw  to  llir  >:nallnr>-  nl    ti,r 

,1,,M'    lltilizr.l.       .I,.WHI->    M-llll~    rnlltimi    lll"M'    nt    (    rai,-. 

lint  ail  liicM'  a.niioiv  IliM  thai  \\um-U  pivvcntm?  j-aiv-i- 
e.f.riii  I-  not  alwav-  Mitruiriu  io  ,,n«liuo  pumatinn.  thus 
,,,„,lH:ni:    n,vr->arv    thr   a.!in:uiM  raiam    nf  ntl.rr    pm- 

illi\C>    llV    lildlltll.  ,,,,-,  1 

K„.vin  i^  an  rx,  ,.,.,lin-lv  ],mu,.|Iu1  alkaluul  an.l  inn^t 
1,.,  i„nullr.l  j.nlh-,nu,-lv.  rn.louKt.Mllv  H  ha^  it-  |>lar.. 
wlu'.i  usrd  in  coiiahiMUs  ,lr-rnluM|  ahuv...  hut  it  -  noi 
of  walo  ],ra.-tic-al  applirat  mn  and  «ill  nrvH'  mna'  mtn 
ovnrral  n-i'  alone  a-  a  -nlu  iitanron<  |aii-alive. 

Milinl'll  111  M.'i  1. 

riri.'-   in  a  ivrriit  |nihli(ation  Mat.-  iliat  la'  ka-  j'lv- 
,,,,v.ra    >o|uhle   -alt    o\-    plirnolplitkakin    wkah    hr    lia- 
,,;„nr,l  -r.doMiillialNl.  an.l  v^l.ali  ar,  onim-  to  ki-  a. .  ,,nnt 
„  h,.in<'  nsrd  snm-rnlk   a-  a  Inpodmnir  |.iii-ativr  n' 
,1,,  ,.:.„„  s  in  Montiu'Uirr.     Hi.  a.rouni   ..I'  tl.r  n,o;le  ot 
,„vuaration   and  of   ikr  .Inanual    |,.o|.Mla  -  ot    t  n-  dr- 
;.p,;,n,.  ;uv  -o  ,.xr,...d:nuK   n,ca,-M-  ikal    no  dHmitr  idra 
„r    M     ,hrn,aal   ,on-lilMiion  ran   hr    'ornird.      l^'""""' 
I,,,,,,        „    I,    I-    tlir    di-odiuni    -ah    ol     phrnolpktlial.an 
,,;„,1,  i;a-al~ol„.,.nd,.-,r,lH.dhN    M,.^^^  and  >la,A.-;  and 
whul,   1-   mad,,  hv   ,l,r  :„ldition   ol    -odmni   livd.oxid    to 
Plienolplnlialcm.     Tl.i-  -alt  i-  vrn  -olnlilr.  and.  hnn^  a 
.onikinationor.  ^..^v  ur.k  and  «  iih  a  noin  -tn.nu  l;a-. 
,,    ,,  ivadilv  hvdroli/ahle  and  art>  like  a  M>lntion  ol  tla' 
,lkalii.-rll':ti,a,  i-.  .t  ,- ,1,- id.dU   irntan,  -     It  ,-^^ll, 
,,,.,Hnl.,v.tti,atxvoa.ai,  llior.|,o,-,oMh..laTa|-nt    ■ 

^imluation  ol  -odoi.lukal^l  n,  lla^  .linir-  o,  M'-H- - 
I,;,;..,,,,,,  iniii.suh-lanm-id.auiral  wil  1,  t  hy  d  i-od,un, 
,,n"o|'  plunolpldliakan.  it  ,s  dilli.ull  to  -r,-  h^u  it  -an 
|,„„-..,1  ona,.oi,nl  of  it-  u  iilat  m- cirr,  i  at  tho  i...in,  of 

lliirrtion. 

'in    \inil    l'"'--     M"'l  •""'   l!o"ntivr"  -laitrd  an  >n\r- 
liuaium   uMlu.   phtiiahni    .nai,.   uith    I'.ntuailai    tvl.a-- 

~..7     Xvrl,    ,„nn,:,.     ,!.■  I't'-'"^" ''   <!.■  <  l..nil>  .  "•ill.  32T. 

.,^^:;^;:;;^;l.::!M;;;!;.;>..-:,;-r 

^^\uu^ 1     aiHl     fxi-i       riPi-M'. 


Iirnlinlls    W'l''   lllllltlllnliril 

:'.ii    At"  1    •ii"!    I!"»iitr' 
I t    ■jai 


•lour. 


,,u-,.  io,l xcrotion.  tl..al-.r,,:,on    a,,    the  iui,;.at.N. 

,„   „„,  ,,|V...t  wf   -uKMU.nion   of   .litlon.nt   i.art~  01    tl,  ; 
uhtln.lr.n     la.lulr     ,.n    tl,.     i>l,a,n,a,ol.>.Mc     artin,,     ot 

''"1;''''^;  ,,,,,v.,l   ibat   nlive  nil   «li.;n  l-at(Ml  woiiM   .li^- 
.li.litl.nl.'iii    ami    llianv    dl'    it-   (Irriv; 

sdiiu'    val'.U'    a- 


.„iN,.  ,,lu^n'oli,htbal,'ii.  an.l  iiianv  ol'  it-  drrivativ,-,  and 


ill;,)    ilii-    (111    itrcparatiiin    ikis.-l'ssoi 


III;,,      ,111-     nn       nf|..ii. ..!-.,.     ,.>..  ...... .. 

,„„.,,;„  is..  wiuM.  injr.tr.l  l.riu.ath  the  skui  ot  .lo,>:^.  r 

It    wa^    -onM    „]is,m-v,m1    that   iiioiv    proloii-.Ml    pui-at.u. 


.,,ioirwa^  ol.iaiiH.l  Nvhrn  |,hrnoli,.trarlilorphthal.Mi«  wa^ 
,,,i|,l,,v..l  than  wlirn  anv  ml,,,-  pliihal.Mn  at  tlirif  rn,„- 
inainl  wa-  um'iI. 

,\ii  riini)  OK  n:r.i'\i;i\'.  "H.  -oi.rTioN 

The   .-ohition   of    ,,li.n.ilt.tra.!i!o,,.l,tlK.I;.in    rnipMra 

,,nva,,l,o„t  tin.  inv..ti^ation  iMMvim,va  uW  u.  10   -^^^ 

,„  „a\  ■      X-itral  olivo  ,m1   i-  -loxvlv  iR'atoil  to   .1  >  (  •• 

M  .lH.n  tln>  t,..u,n.rMl.nv   i>  n'a.l)o.nim.l>- j.ow,l.;,;M 


honoll^'fa.-hlorphthal.ni  :-  -Mol  with  >t.rrn„'.  Iho 
lioatin.  H  .ontinuM  lor  no,  l„n,..r  than  in.  nunuh. 
and  tiu'  Icniporatuiv  1-  no,  allownl  to  cxev.M  -  -H  ■ 
ironler  to  rnnov.  anv  tra.v.  <,f  for.M^n  n>att,T  or  un- 

lL,lvc.a  phthaU.iu.  th.  uil  .olut.on  i.  l,lto,v,l  ho.  m  ■- 
4.M-iliznl   thi.-k.  ana   M   a-i.lo   Un-  u.-o.     '  ''^o  o  1     hu> 

tivatoa  u,ii  a,-soiv,.  tiu.  .hioi-  hoav  „.  'i-  .■vt|;  <  :'i 

.,l„,„t  0-'  .nn.  to  rvci-v  li>  (.r.  ol  ,1,1.  Nvlnlo  it  «i!l  li- 
lolvo  phonolpluhaloin  uxM  ,0  a  -li-htlv  .LMvafr  .vtmr 
a!  a  -liL'litly  lour,' tmip.a'atinv.  ,.,,„.   ,,,.,t 

Analv.uai  ..xpo'inu'nts  w.av  niaa,.  «li,rh  >hou  t  at 
no  ni.p,v.-iahh-  s.ponilhation  ot  ,!,.  oil  tak.-  1. . 
,l„nnyth,sp.-or,>ann..  NVvH'tl,..!,-.  :n  onh  ,  t„  h-- 
til,.  rr.k  of  Miponiliration.  tla'  .  ,i-toin  vva>  aaop,,.a  o| 
vpa,-,n.  onls  in  ry.  of  -n,),  a  -olution  a.  a  Uuu. 
Iho'.yl,  aonl.tl..^  la,-..'.-  vnliiiii...  n,  ,h.  sohu.on  nn.ht 
III'  in-ciiai-fa  at  one  opci-ation. 

,,,;„„,,,,„l,;,l,i,i   rNliilMl-  a   u.vatr,-   ,.a,.h.„rv    t..  .niiH. 
a.nvn   onl    of  >,i,li   a    -oiiUmn.  'mt    a   p,-op-,'lN    p-vpan', 
,„h,tion  of  tl,.-  rhlor  hna.v  «,ll  -.a„a  -unio  Mav-  u„l.M,t 
jim-  picripi,!,,!'!],  whatcNc,'. 

\„mM;,',,ON.    I\.  ,il,,10N     NM'    M-iM,   Ml-    V.    i,ov 

p,„r,„v  Hilr.m..  01,  ,h.'  :rpo,-t  .0-  ,hr  rlmiral  applua- 
,,„„  „,■  ,lM-  M,l.-tan,r  a  f.u  vv^nl  .omrrnmu  H-  a-.- 
'„ip,H.M.  ,1-  fa,,  .n  th.  IhM;.  „-,han,,.l^ol  ,.M,v,,on 
.,,,,,1  „,,nna,...f  a.tiM,,  uill  n"t  1"    ■■"!  ''1   Pl='-'. 


I'rariiralU    all    lln'    'Ii'h.l:    n    a'liMM-iicil     '  >.in    tlii'    l"cal 

(.ral     nl'     ;•    jcrlinl'     lllt(.    tlli'     L;cll-I'ill     ri  I'cll  la  I  H  ill     ill     rroMl 

-ixt.i'ii  tu  t\\riii\ -four  liuiii'-.  It  a|i|>(Mi--  in  tin'  I'ilr  in 
ihr  cnii  jiiLiali'il  riii'in.  aiiil  lain'  ;n  luali  llic  \'\r<-  ami  mii- 
jn::ati'i|  lonililimi.  ami  mm  luir-  id  lie  ixcirtrii  in  tin' 
liiir  nl'  a  liiliai'N  ti-tnia  il'"j  ini-  I'r.iin  lui'l  \ -ci-lit  \<< 
-r\riil\-t\vii  lii>iir>  ami  in  llh  (rw-  n|  a  "jTiiial  iI'il;  a> 
|..ii-  a~  li\c  ami  -i\  ila\-.  I'arl  (if  tlii'  iliai-  i~  rc- 
ali-mlird  a,-ain  \'i"\\i  llir  lai-r  iiitc-i  im-.  ami  'lir  |Mn\i:- 
aii\raiti"ii  hKidiicrd  i-  r(iii-i'i |ncn 1 1  \  M'l'N  |ir(il'tii.irc(l  in 
iiaiiiiv.  Nil  ira<c-  nf  ihr  (liaii;-  i-an  In-  clftoitci!  in  tin 
iivinr:  ii  iliii- (lilTrr-  ri'i.in  |iliriin||ilitlialrin.  wliiili  al'trr 
licinu    injnic'l    iimliT  llic   -km   rMa|ii-  tu  a   i  nii-idrralilf 

drL;i'rr  li\    ua\    i>\'   1  llr   kidnr\  -. 

,\i;i  i-  a  |ii'iil(in::rd  imti.hI  nl  r\|iriinicmaliiiii  in  a 
-('Mr-  of  \'ny\\  llijfc  tiiUl-  ill  doi^s  it  wa-  Iranicd  tliat  in- 
JiciKill^    iif    till-    liniK      ill     IKIltial    l>ii\c    (111     \\('1V     mil      tnl- 

\,,\\ri\  l,\  am  nntuuard  iv-ii!t-  ntluT  luiall\  at  tlic  iimiit 
(,r  iiijcctiiiii  iir  -.\-ti'inirall\ .  and  tlial  mi  -\-triii  otiicr 
than  tlir  aiiiiiriitaiA  wa-  inHiiiaurd  li\  tin-  -iili^tamn. 
It,  iiitn.diiili'iii  iiitii  till  di-|ii'n-ar\  and  ward-  nl'  tlif 
li,i>|iital  I'mt  liirtliii'  iiwr-ii^iatidii  \\a-  i  lirirlVirc  ( mi-id- 
fivd  Jn-titialil.  and  ad\i-ali'  ■.  A  -tml\  tn  dcipriniiic  il> 
ilinical  \aliii'  \\a-  ai  (  nrdiiii^lv  iiiidcrtakrii  at  tlio  siiir^rt's- 
tinii  .if  llr.  All!  1. 


\ii\i  I  \  i>ri;  \  1  iH\    1(1  iiii>i  iTi.'it  \K  r\rii:\i- 

'llli     til-t     -I'lK  -    nl'    lllji'l  1  mil-    WiVr    Iliad,'    ill    till'    'ill-trt- 

ri.al  uard-  li\  llir  |icriiii  — mn  nf  l»r.  Williani-  and  willi 
the  kind  a  — i-tamr  nf  |ir  Slmr-.  Tin-  ra-i-  i('|iri-cnl 
\\((|lli|l    ill    till'    |ill(  r|n|llllii,    siilllc    111'    uliiilii    ICi  rived    tlir 

iiijci  Iimi  111  plair  <ii'  tin  ii-iial  initial  piirLiativc  while 
e.liiei-  ie(ci\e(l  ii  when  a  |Mir,i.'al  i\e  wa-  imiieated  later 
(JiiriiiL:  the  Ui'i'i-iii   |ieriiid.     'I'lii-  talile  al-n  imliKie-  tin 

|V-ll!l    <'\    dlle    injtilHill    (if    r.'    e.i  ,    111'    the    "il     pre|ia  mt  I' ■!! 

•.;i\eii   tn  a   di-pc'n-ai\    |iaiient    (Nil.   ."■.   Ml-.    I!.).     'I  hi- 

,  a-i     I-    null!  led    here    heian-j'    "I'    the    -iiiallne--    nl'    th( 

i\<>"'  adlllini-lel'ed. 

Si  !:•  I   I  v\i  Ml  -    I  \.i  I ■-  -    .•!      I'm  \"i  II  I  im  III  ■■mil  I  M  VI  I  IS 

IlilV  liiiv^ 

i.r  iiiic.       rdliiw  lilt;  in|i.  Il.ili 
I  Ills  I  I'v  I  II  \  1 .     lien      I       ■-'      a       1      .'.      !'■      7 

I'Mii.iii-    1.1.  hill-    II  J    ;;iii        I     Ml-    II  (      n      I      e 

111    n r  nil  -    Ml-    A  1         ■-'      "      'I      I 

.;   Mr-  i:  I      I      I     11     I     II     1 


I'litii'iiu    r Ulin:    II  ::    l'ih        I    Mr-    .\ 

ill    1.-.  (■  (•    (if  oil.  "•    Ml-   I' 

i;   Ml-   I 


I  'J  II  I  'J  J  -■ 
:;  I  (1  1  I  II  I 
(I     1      II      I      I 


■yiu-r  ivMilt-  ,iiv   iini   ciilnvlv    -:ii:-rait,ir\.  iuil    iii   \\u- 

Ijohi     ,,|'    laliT    r\liiTlc|lic-    lill-    :-    lll'iUi^lil     t(i    l>r    (llh'    In 

ill".'  la(T  tliai  tlir  iImm'  ailniiniM(Mv,l  wa-  tn,.  -mail,  ami 
|,i,,l,alilv  had  the  <1om>  Ihtii  lar-cr  ilir  ivMilt-  wmild  lia\r 
l,,rii  in'riv-iKindinulv  hkhv  Imdrahlr.  llci\\r\rr.  a  di- 
,id(<l    laxalixr   .■iV'Mi    u:i-   ul,iainrd.      'I'lir   MnnU   liccaino 

.nflrl-    and     in    .-iimr     in-lailcr      -i'llliflnid    "l'    "f    \\\r    '-"11- 

,|,l.  n.  \  <<i  a  |i(.i  I'id.^r.  :ind  ni  nn.'  in-laiiw  cciulainiil 
ill,.  ,l;i.M  a-  late  a-  tlh'  liltli  dav.  In  nunc  >>\'  iln'  '-a-r- 
did  Ideal  ii'i-itati"n  m-  iiillanniiat  inn  Inlluu  iln-  in.jrdi'in. 
n.ii'  wviv  uiipm-  |iair.-  "T  i"ii,'  .-oniiilaiiKMl  uf  l,\  aiiv 
],;iii,.nt  at  aiP  linii'  inlinum-  ilir  adniiniM  I'al  mn.  Tin' 
iiiin,.  nnd  tlw  milk  \W'iv  r.,llrc1r,l  frnm  the  niothrr-.  Iml 
,1,,  ilni-'  .  ..nid  lir  drltvlrd   in  ciiluT  Mvivihm. 

A  nUcci'in  -n|i|Hisit(ir\   wa-  L;i\cn  at  tlir  md  ol   iliiny- 
-i\    Imni-    wlii'H    nr(v-ai\     I'M'    tlir    tii-t    Min\  .aiicnt .    and 
|.,,|„,,,,,,,1   if  iliirn   ,iv  li,mV-  a::ain   inlri-\i  lud   withniii  an 
.  \,-unati(>n. 
|,i  „,■,  i-,  ,,i     \i.\iiM-ii;\  I  i"\    iH   |li-l■l;\-\l;^    r\iii:M>< 

'I'lic   rc-idt-    jn-l    |ni-rnird.   indiiL^li    nut    rutindv   -al;- 
Inrlnrv.    wriv. '|mi\\v\(  !•.    -iitVi. wnt    In    .in-|it\    a     fnrtlin- 

in\,-li-ati I-  ti^   ll.r    \aliir  "!'   iIm-   Miiiriiianmu-    la\- 

,,li\r.  partunlarlv  in  mcu  "I'  tlir  pn.lnn^iiMi  nature  n\ 
ill,.  ,|,il N(  ivtrd  tliinnolii.nt   a   [ifind  of  -f\cral  dav>. 

Til,.    jMtlrht-.    indiratc.      nil    llic    laMr    invM'lllr.l     l.i'lnu. 

^^,.|v  -.■livlvd  .a~.-  Ml  ,lir.,iiir  r.iiiM'patHiii  niitainrd  iVmn 
III,.  Ill, dual  di-|.riw.irv  nl  ilir  .Inlin-  lln|,kin-  II(i-|nial 
ill,,, null  tlir  ,.mrn-v  nn.l  a-i-lam,-  nf  l»r.  McCiac-  and 
,|„,  ,,||„.|.  iii,.|iil„.|'-  'n\  tlir  di-|.rn~ar\  -talV.  (»nl\  mair 
|,;ill,,|lt.    u,.|v    -clnl.'d    111    \\li"in    th-    ~\in|itnm    ••rhi'onir 

.nn-IIIMlmn"     ...llMllntr,!     tllc    rhlr!     .an-r    ni    r,HII|daillt 

•|'|ii-  -\iii|i|,m!  \,inr<l  III  ilir  .iillVniit  iiidix  ida.' '-  tn  all 
,|,.u|v,.,  ,,r  -..•\.'iit\.  and  ha. I  |»Mr-i-lr,l  lor  |,crin,!-.  \ai\- 
iiij  li.Mii  wrrk-  m  lucntv  \rar-,  Manx  n|  ih,  iia.lienl-' 
|i,i,|  |„.,.n  icliirnini:  tn  llir  .lini.  \nv  mniiili-  -r  \rai-. 
i,,.\,.r    hmin-    a    Imud    iiKix.incnt     uiilann     ii-.nt  in-    In 

,||l!-~         .•<n||,,      iv-|inndrd     urd     In    d.ailv     An~,'~    nf    (.iMilM. 

I,,  pill-.  ,ir  1,1  \annii-  tnim-  n|  Ira-,  v.hilr  nihii-  ha,l 
,|,,n\,.,l    Iml,.   ui    nn   Umrlll    Imiii    aiix     Inrm   nl    |,irMnn- 

inaimcnt 

In, I, a  a-,  plu  pi. .  ant  mii-  'm.  h  "I  lii'-r  |ialirnl-  wa- 
^l\,.||  M.  I  ^1,1,  ,,|  p||,.||,.llr|ia.  Iil.ii|ihlliali  111.  -.'"I  .  .'  .  nf 
J"|i,.  ||,.-||K  pivjiaivd  .nl  piv|iai,ilinii.  -iiUnitam  .m-lx  in 
,1„,    .|,it,.al    n-inii.      l-'.a.h    .u..'    xva-    a!-o   -npplird    uith 

lUn    -h.rlin    -Iipp..-lt..ll.   -    I     \*a-    ad..-.|     |..    \n\\n\S     i|l.-0 


10 

nil,--  (1)  ill-ink  «alri-  invlv:  [■> )  .-at  >oni-  Irnit 
,,.„!,  ,l;iv-  (.'.)  lake  walkiUL:  rxn-cisc  even  dav:  (1)  -:" 
1,,  inilrt  ni-lit  an.l  ni..nnn^  ai-al  >tav  ilvo  to  Im  nmiutr- 
y;  ,„.,,.-sH-v:  C.)  UM.  a  uh.'-in  -n;,pn-itn,-v  al  inc  rK- 
,,.„,nu  ..r  tliirtv-MX  h.mi--  if  i1h-  Im'«.-U  liaw  imt 
Inuv^.L  an,l  ii-r  llu-  utl.n-  -npi'n-itorv  latrr  il  tliii-ty-ix 
]i.,in-  a-aiii  pa-  willanit  an  .Naiiialinii. 

li.iy  IM>^ 

nlhij..,-      f..ll.>«in}.' iuj.riinn.  -Ja        :;'! 

T    M    K       ..         111"!' uu-n,-il 

--    11.'  1         1-1111'  nnii.'M. 

..,.,,,..  7  7      N"       i-riurii       111 

'.•.!."'■        •  •         1      -      1      -      1      '      -  ,..iiMi|.ation.* 

,       ,       ,       .,      1  s  T      N"       return       "f 

1"    1    I'  1      .1      1       1       I      -      i  (iiiisliiMUi.in." 

,      ,       ,  ,  :;     c.m.^niK.linu    vr 

1  1    -I    >  '       ■  turnrd. 

1  7  7      No       riMiiiii       "1 

rj     11,    <;  1  -_-■•---'  ,ull'iti|.alinll.* 

H    1    W.       ■  ■         11-"!"'  ,„,,,„Ml 

1.-.   1,    1.,       ■  ■        -      '      ^     -  -  tiun.'il. 

,       I      II      1         1-J  >'      Nil       i-''t"ni       "I 

IC,    .1     S  1         1        n        1         I  '-  ,,,nsli|„lti..M.' 

IT    1.    K  1         1      II      1       ■       I  luninl. 

1^   .1    i:                  .,1111  ,niisii|iaihin.* 

,1111  .".          i;     Nil      I'l'tiii-ii      111 

r.i   1'    1,        1        1      II     1      1      I      !      I  .■(iiiv-iliiiiiiiiM,* 

II  .  ,         .  .       Kisiili               mil 

-.Jii                    1        ---"■'"  '  '                      kiiiiwn, 

-Jl    II    N                    1       I       1       1       I       1       '  iiiriii-il, 

,,1111            7  7      Nil       M'tui-ii       I'f 

-J   .1,  \V          1         I       1       1       1       1       I       '  .■,,iistiiiiilli.ii.* 

,  Nil       ritiii-n       111' 

■j:-.    W     II       .            1       --      -      1 ,,,Msii|iilliiiii  * 

■J)    I'.    V\          1         '-      7      ■■•      'I' "1^ '•'"'■'"'■■'  tVinstiimtiiiii'init 

-.-.    I,    M                    111'"  ivll.'Vi'd. 

,       ,       ,       I       ,       1       ■'  V           s      N.I       i-i'tuni       "f 

•jr,    .\    r.          1         J      1      1       1      1       1      -  ,nnsti,iali..ii,' 

1  n         II      inii-^liimiiii"     "■ 

■.'7     .1      ^^  --""""  llHIli'll 

,,     ,,  .  .       No    ilT.ii 

■js    \\,  r.  ',       11       1       1       1      1         't  7      Nil       .■■■nini       nf 

•ji.i    W,  r.         !         1       I       I       1       '       '       '  .■oiisiii.allnii,' 

•"'   it.    ivluii.    't    '..n'n|.:!'i.'n    MM.';    ,.in.'.'N    v-vln^    rm,,,    .«■.    1'- 
Kl\    iii"lith> 

|,r     i;..-.  nlli:il  -   l'""'  '" 

,,,„,  ,,[  ,;  ni"-i  -liikiiiL;  |ilirn"in'-iia  ivM-alnl  \<\  tin- 
,,„,^  1,1  ,1,1,  tal'li-  1-  111'-  |ir..lim.-i-il  niHuiv  "I'  tliu  action 

,,,,„1,„,„1  i,v  tlu-'iMi^.  It  I-  1.1.1  .knn.nl  thai  oni.  mjcv- 
„m  will   I'Vo'liar  |M,v.,,u...n   I'.riM'.iv  llia.i  loiu-  or  tl^'■ 

dav<    linl    llial    II    u'-     .1"  tin,,  anil  that    .Mh-nt  lla-aMl 


11 


lllrllt-    nil    iIol;-.  ,.  ,  , 

It  Mil-  iK.i.r.l  iliat  111.'  -ur.r.-  aiirii-liiiL'  tU'  observance 
,,,■  ,|„.  In.'iHiir  and  .li.lrth  nil<-  -ntlmr,!  abuve.  .Innns: 
,1,,.  |„.n,„T  ,n  ul.u-ii  'lail'.  w'^ruu■u\^  oi  ti.r  'nuwcs  were 
I,,,,,,-    iM.iiirr,!   ■n^    ill.'  .li!-!'   innlv.   un,,!  1   rncouni-e  the 

,,,,i.:n-  1"  rn,„iniir  in  li UM.r\an.v  ni  ilu-c  nilc-.  and 

ihMi  il:,\  unnl.l  ihii-  -Mam  a  jin manci.t  <  inv  without 
rnilhM-'n-.rl  to  ,lni.-.  Th,.  NNa-  ivaliz^.l  m  wn 
,,„,,„,,., lit  of  lii,.  lu.ntv-mrraM.-  o!  ,liivn,r  ,-.inMipa- 
li,,n       Tiiat    ih.'   tuial    iv-nlt-    iv,nr,h.|    .hinn-    tlir    hr^t 

U,rk    InlluUIll-   injrrllnn  aiviiot    ,  i  m '  i  o  |  i-v -h  h  ■    h  N  ,u  I  mU' 

;,n,l  ,liri,tir  livalnirn,  i-  i-iun.,!  1,v  tli.  fan  that  inanv 
,,!•  ihr-r  -aiiH-  i.ati.nl-  ^^'■yr  <M  .li-i-'n^uw  ra?o^  who  had 
,,,,,l,.,idv  had  llir  >an.r  -iiu-r-lions  and  advice  on  nniner- 
!,„.  pivMon-  Ni-it-  a-  u>.ll  a-  hv  the  Minihir  iv-„lt^. 
;d,vadv  ,ieiilion,.d.  v,hi,h  w.n- nhtained  m  aniinaN. 

I,  ,,  x,.r\  rNiilciU  that  piiriioitctrachloriihthahan  i< 
n,,t  an  idral  inii-alivr.  S.Arral  -cnmi-  „h.,crt  lo,,-  at 
oIK  !■  |iii-ciit   iheiiiM'lvc-  ; 

1     ■riir  iii-nliihilitv  of  thi-  dm-  111  \witcr. 

•/.   The  -!i-lit  .'ic-r >l'  il-  -oliihilitv  111  oil  n-rr-itat- 

jii,.  ii  lar-c  voliiuH-  l"i'  injcclioii. 

~,    -i-h,.  \nvi  time  <la;iMii-  hdniv  il iisct  ui  it^  hi.\a- 

,u.,   .iHion.    uhich    appear-    n-nailx    .'iohtc.n    to    twcntv- 
luiiv  ho.ir-  after  adinini-t  rat  i..n  of  th.e  dru,<:. 

I.  The  mild  ehaiaeier  ..f  it-  a.tioii.  wliieli  I-  rather 
hi\al  i\e  tlian  ]eir^ati\e. 

\,  ,1,..  -Mine  time  -exeial  red.vmin-  teatiire-  uhieli 
„„Kr  till-  -iih-tan.e  ,,f  peeiiliar  xaliie  mii-t   not  1 vef- 

Inukr,!: 

1     'Idle  pi.^lon-ed  miliire  of  It-  action. 

•/.  'n,,,  .ii.-ni.e  of  -aiiipN  pain-  ami  enli,  thronehont 
the  period  of  It-  aetion. 

:;  -rheeun-taii.  .  at  lea-t  in  tiie.a-e>-..  lar  -tndicd. 
^,1,1,  whi.h  it  ha-  produced   ie>iilt-. 

l-hrllollHraehlorphlliah'in.       thell.       l-       elllelellt.       lioll- 

,,,xi,.  and  iiMiMiiitant  ulicii  adniini-tered  a-  a  -ii  mii- 
,,,,,,.,,11-  piir.atue.  hin  Its  in-oluhilitv  iii  «ater  an.l  tt- 
l,nv  -oliihilitv  m  ..il  -lan.i  m  the  wav  of  it-  uide  ap)) h- 
,,,i,.n  a-  -II. h  in  pia.tieal  i  herapcit  u-  hut  do  i„,t  d,- 
,,,„,  |,,„„  „<  ,.|Vuieii,  V  uheii  a  -,il.,iilane,ni-  pi.r.^ati^e 
>-  imli.alcl.  It  imn  pi„x,.  „f  .  on-i,lerah!e  vain,,  m  eei- 
i,;ni  ,,Mi,litim,-.  a-    lai    m  e,,ma  ;    (h)    m   iiiarkd   -a-tio- 


Vi 


iiiu-tiii;il  ivnialiiiit'.  wliicli  ciiiiniinili.  iiir-  lli<'  ;i(liiiini-^ 
tratiou  III'  :i  pin-uatnr  hv  iiuuitli :  (ci  am-iii:  ili''  in-.;ii.'. 
wild  often    rcl'usc   l-'  lako  aiiv   mcili-iiic  l.v   mniuli   jna 
wild    liulil     viirorduslv    iiffiiiii^t    tile    iMlinini-iratidii     of 
,.,„.niiiiii;    (.1)'  ill   (■.Ttiiiii  ca^o  df  clir-ni.    ,.mMi|KUidn. 
cdinhiiicil  with  liVLnonic.  did. 'tic  ami  ii~v.lii.    t  natineiit. 
riifiioltcti-aclilofplitlialcin  i-  w<.iih.v  df  a  trial  in  the 
fi,.|,|    df   al"ldiinnal    :-iifp-r,v.    wlicn    iU    nil  n»liaii..ii    iir- 
ncalli  tlH'  -kill  ran  lie  a.coiii|ili-lif.i  (liinii-  l!ie  aiic-tiM  Ma 
witlidiil    aiiv    iiaiii    v,  lailrvcv.   wlunv    it-   iniM    |nn|nii->Ml 
laxative  elVeel.  e.  ,-..  a   -if,   Jailv  -td,,l.  -lartiii-  dii   t!:e 
(lav  fdlliiwini:  llie  d|.evaliMii  ini.i  cniit  11111111-  for  a  |.enn.! 
nf'fnnn   fmii'  to  m.n  day-,  inay  jid^r-ildy  eiitirelv  di-|irn-e 
with  tlie  neees.-itv  df  adinim-IerinL;  any  etliev  |iiir-at  i\<' 
liv  ni(.iitli  diivin.tr  tlie  lir-i   uerk  -iik>(M|ii.nt  to  tlie  oprr 
atidii. 


